Prof. Massimo Padalino | Medicinal Chemistry | Excellence in Innovation Award

Prof. Massimo Padalino | Medicinal Chemistry | Excellence in Innovation Award

Prof. Massimo Padalino | Medicinal Chemistry | Professore associato at University of Bari, Italy

Dr. Massimo Antonio Padalino obtained his M.D. from the University of Padova, Italy, in 1995. He completed his residency in Cardiovascular Surgery at the University of Padova Medical School (1995-1999), where he served as Chief Resident (1999-2000). He pursued advanced surgical training through prestigious fellowships, including a Surgical Clinical Fellowship in Cardiovascular Surgery at the Mayo Clinic, USA (2001-2002), and specialized training in Pediatric Cardiovascular Surgery at Boston Children’s Hospital, Harvard Medical School (2002), and Mott Children’s Hospital, University of Michigan (2003-2004). He earned a Ph.D. in Cardiovascular Sciences from the University of Padova (2005-2008) and further specialized with a Master’s degree in Cardiovascular Pathology (2011) and Pediatric Cardiology (2014). Additionally, he completed a research fellowship at the Cardiac Registry, Harvard Medical School, and a visiting fellowship at Johns Hopkins Hospital (2015), solidifying his expertise in congenital and pediatric cardiac surgery.

Professional Profile : 

Orcid

Scopus 

Summary of Suitability for Award:

Dr. Massimo Antonio Padalino is an outstanding candidate for the “Excellence in Innovation Award” due to his pioneering contributions to pediatric and congenital cardiovascular surgery. His research has led to innovative surgical techniques for congenital heart disease, particularly in neonatal and single-ventricle repairs. His work on novel bioprosthetic materials, cardiac regeneration, and mechanical circulatory support (ECMO, VAD) has significantly improved patient outcomes. He has also played a key role in international registries (EUROFONTAN, EUROAAOCA) and multicenter studies, advancing global knowledge in congenital heart surgery. His collaboration with premier institutions like Harvard Medical School and Mayo Clinic further highlights his commitment to innovation. Dr. Padalino’s groundbreaking work in pediatric cardiac surgery, including innovative surgical strategies, regenerative medicine, and advanced circulatory support techniques, makes him highly suitable for the “Excellence in Innovation Award.” His contributions have transformed congenital heart disease treatment, making a lasting impact on the field.

🎓Education:

Dr. Massimo Antonio Padalino obtained his M.D. from the University of Padova in  Italy.  He completed his residency in Cardiovascular Surgery at the University of Padova Medical School (1995-1999), where he served as Chief Resident (1999-2000). He pursued advanced surgical training through prestigious fellowships, including a Surgical Clinical Fellowship in Cardiovascular Surgery at the Mayo Clinic, USA (2001-2002), and specialized training in Pediatric Cardiovascular Surgery at Boston Children’s Hospital, Harvard Medical School (2002), and Mott Children’s Hospital, University of Michigan (2003-2004). He earned a Ph.D. in Cardiovascular Sciences from the University of Padova (2005-2008) and further specialized with a Master’s degree in Cardiovascular Pathology (2011) and Pediatric Cardiology (2014). Additionally, he completed a research fellowship at the Cardiac Registry, Harvard Medical School, and a visiting fellowship at Johns Hopkins Hospital (2015), solidifying his expertise in congenital and pediatric cardiac surgery.

🏢Work Experience:

Dr. Massimo Antonio Padalino has over two decades of experience in pediatric and congenital cardiovascular surgery. Since December 2023, he has served as Pediatric and Congenital Cardiac Surgeon in Chief at UOC Cardiochirurgia, University of Bari, Italy. Previously, he was a senior Pediatric and Congenital Cardiovascular Surgeon at the University of Padova Medical School (2004-2023), where he independently performed approximately 150 complex congenital heart surgeries annually, spanning neonates to adults. His expertise includes neonatal heart surgery, single-ventricle palliation, heart transplantation, and mechanical circulatory support (ECMO and VAD). His clinical training includes tenures at leading institutions such as Mayo Clinic, Boston Children’s Hospital, and the University of Michigan. He has also been actively involved in postoperative intensive care, clinical research, and multicenter studies, significantly contributing to advancements in pediatric cardiac surgery. His leadership extends to mentoring and training the next generation of cardiac surgeons.

🏅Awards: 

Dr. Massimo Antonio Padalino has received numerous accolades for his contributions to pediatric and congenital cardiovascular surgery. He is a Fellow of the European Society of Cardiology (FESC) and has been recognized for his expertise in congenital heart disease management. His work in innovative surgical strategies and regenerative medicine has earned him invitations to speak at leading international cardiology and cardiac surgery conferences. He has also received research grants for pioneering studies in cardiac regeneration, bioprosthetic materials, and surgical outcomes in congenital heart disease. His collaborations with renowned institutions, including Harvard Medical School and the Mayo Clinic, have strengthened his reputation as a leading figure in pediatric cardiac surgery. His research and clinical excellence are reflected in his numerous high-impact publications, which have significantly influenced advancements in congenital heart surgery and pediatric cardiology worldwide.

🔬Research Focus:

Dr. Massimo Antonio Padalino’s research focuses on congenital heart disease surgery, particularly early repair techniques and novel surgical strategies for single-ventricle physiology. He actively contributes to international registries, including the EUROFONTAN and EUROAAOCA, studying surgical outcomes in congenital heart defects. His work explores innovative approaches to preserving pulmonary valve function in Tetralogy of Fallot repair and alternative strategies for managing end-stage heart failure in children, including ECMO, VAD, and pulmonary artery banding. Additionally, he investigates heart transplantation in congenital heart disease, cardiac regeneration in infants with dilated cardiomyopathy, and bioprosthetic materials for cardiac tissue reconstruction. His research also addresses the neurological and pulmonary effects of cardiopulmonary bypass in pediatric patients, aiming to improve outcomes and long-term survival. Through clinical trials and multicenter studies, Dr. Padalino is dedicated to advancing pediatric cardiac surgery, refining surgical techniques, and enhancing postoperative care for children with complex congenital heart conditions.

Publication Top Notes:

Heart–Liver Interplay in Patients with Fontan Circulation

Authors: Not provided in the given data

Year: 2025

Citations: Data not available

DOI: 10.3390/jcm14041114

The Impact of Dominant Ventricle Morphology and Additional Ventricular Chamber Size on Clinical Outcomes in Patients with Fontan Circulation

Authors: Not provided in the given data

Year: 2025

Citations: Data not available

DOI: 10.1017/S1047951124026581

First Report from the European Registry for Anomalous Aortic Origin of Coronary Artery (EURO-AAOCA)

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1093/icvts/ivae074

Current Understanding and Future Directions of Transcatheter Devices to Assist Failing Fontan

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1016/j.jscai.2024.101334

Intracorporeal LVAD Implantation in Pediatric Patients: A Single-Center 10 Years’ Experience

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1111/aor.14716

Late Gadolinium Enhancement and Anomalous Coronary Aortic Origin in a Large Paediatric Cohort

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1093/eurheartj/ehae545

Percutaneous Approach to Residual Pulmonary Bifurcation Stenosis in Conotruncal Diseases

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1017/s1047951123000999

Postoperative Outcomes of Fontan Operation in a Multicenter Italian Study. How Far Have We Gone? Early Outcomes After Fontan Operation

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1007/s00246-024-03642-2

Successful Implantation of HeartMate3 in a Small Child After Multimodality Imaging Pathway to Assess Feasibility

Authors: Not provided in the given data

Year: 2024

Citations: Data not available

DOI: 10.1097/MAT.0000000000002069

Overshoot of the Respiratory Exchange Ratio during Recovery from Maximal Exercise Testing in Young Patients with Congenital Heart Disease

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.3390/children10030521

Three-Dimensional-Enabled Surgical Planning for the Correction of Right Partial Anomalous Pulmonary Venous Return

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.3390/jcm12020472

Chronic Heart Failure in Children: State of the Art and New Perspectives

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.3390/jcm12072611

Effect of Preoperative Pulmonary Hemodynamic and Cardiopulmonary Bypass on Lung Function in Children with Congenital Heart Disease

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.1007/s00431-023-04926-0

Hybrid Approach for End-Stage Heart Failure Treatment in a 6-Month-Old Baby

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.1017/S104795112300046X

Late Left Ventricular Myocardial Remodeling After Pulmonary Artery Banding for End-Stage Dilated Cardiomyopathy in Infants: An Imaging Study

Authors: Not provided in the given data

Year: 2023

Citations: Data not available

DOI: 10.1016/j.ijcard.2023.05.040

Dr. Sphelele Sosibo|Medicinal Chemistry|Best Researcher Award

Dr. Sphelele Sosibo|Medicinal Chemistry|Best Researcher Award

Dr. Sphelele Sosibo, North-West University, South Africa

Dr. Sphelele Cyril Sosibo is a Senior Lecturer in Organic Chemistry at North-West University in Mahikeng, South Africa. With extensive research and teaching expertise in pharmaceutical chemistry, Dr. Sosibo specializes in drug discovery for combating bacterial resistance and Alzheimer’s disease. He holds a Ph.D. in Chemistry from the University of Johannesburg, where he focused on molecular modeling of hydrolase inhibition. His research skills encompass synthesis, NMR, LCMS, and computational modeling, making significant contributions to publications on antimicrobial and anticancer compounds. Dr. Sosibo has supervised multiple graduate students, led various research projects, and actively contributes to academic and community outreach.

Professional Profile:

Google Scholar

Orcid

Scopus

Summary of Suitability for Award:

Dr. Sphelele C. Sosibo is an exceptional candidate for the “Best Researcher Awards,” as demonstrated by his extensive accomplishments in both research and education. His research on antibiotic resistance and bioactive phytochemicals showcases his innovative contributions to the field of pharmaceutical chemistry. Additionally, his strong record of teaching excellence, highlighted by the Certificate of Faculty Recognition in Teaching and Learning and multiple Certificates of Merit from the University of KwaZulu-Natal, reflects his dedication to education and student success. Together, these attributes underscore his impact as a researcher and educator, making him a deserving nominee for this prestigious award.

🎓Education:

Dr. Sphelele C. Sosibo’s educational background is a testament to his dedication and expertise in the field of chemistry. He earned his Doctor of Philosophy in Chemistry from the University of Johannesburg, where he focused on molecular modeling for drug discovery related to Alzheimer’s disease and antibiotic resistance. His Master of Medical Science in Pharmaceutical Chemistry from the University of KwaZulu-Natal involved the synthesis and characterization of novel ligands, showcasing his proficiency in organic synthesis and catalysis. Furthermore, his undergraduate studies, including a Bachelor’s degree in Applied Chemistry and an Honours degree in Chemistry, provided a solid foundation in the principles of chemistry, culminating in a mini-thesis on potential antimycobacterial candidates. This robust academic journey has equipped Dr. Sosibo with the knowledge and skills necessary to contribute significantly to pharmaceutical research.

🏢Work Experience:

Dr. Sphelele C. Sosibo has a robust academic and research background, currently serving as a Senior Lecturer in Organic Chemistry at North-West University in Mahikeng, South Africa, since November 2022. He teaches both undergraduate and graduate courses while also conducting and supervising research focused on drug discovery. Prior to this, he held the position of Lecturer in Organic Chemistry at the same institution from January 2019 to November 2022, where he guided master’s and PhD researchers. His earlier experience includes a Lectureship at Durban University of Technology, where he taught analytical organic chemistry and supervised BTech research projects. Additionally, Dr. Sosibo gained international research experience as a Research Fellow at Uppsala University in Sweden and worked as a Research Assistant at the University of KwaZulu-Natal, contributing to organic chemistry research and laboratory management. His commitment to academic support was further demonstrated as a SI Leader at the University of KwaZulu-Natal, where he provided assistance to students in General Chemistry.

🏅Awards:

Dr. Sphelele C. Sosibo has received several notable awards that underscore his excellence in teaching and academic performance. He was honored with the Certificate of Faculty Recognition in Teaching and Learning from North-West University in 2021, highlighting his commitment to high-quality education. Additionally, during his time at the University of KwaZulu-Natal, he earned Certificates of Merit in Environmental Analysis III, Materials Chemistry III, and Physical Chemistry II between 2008 and 2009. Furthermore, Dr. Sosibo received Dean’s Commendations for his outstanding academic achievements in his BSc in Applied Chemistry and Cellular Biology, reflecting his dedication and excellence in the field of chemistry during his undergraduate studies.

🔬Research Focus:

Dr. Sosibo’s research primarily revolves around drug discovery, specifically targeting infections caused by resistant bacteria and Alzheimer’s disease. His work involves theoretical and bench-scale applications of organic, biochemical, and microbiological techniques. He employs various methodologies such as molecular docking, molecular dynamics simulations, and DFT calculations to investigate the interactions of bioactive phytochemicals and novel ligands with biological targets. Dr. Sosibo aims to develop innovative treatments for both communicable and non-communicable diseases, contributing to advancements in pharmaceutical chemistry.

Publication Top Notes:

  • Dual targeting approach for Mycobacterium tuberculosis drug discovery: insights from DFT calculations and molecular dynamics simulations
    • Citations: 20
  • Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential antimycobacterial candidates
    • Citations: 18
  • Understanding the Hsp90 N-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and
    • Citations: 16
  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N, N′-dioxide ligands
    • Citations: 15
  • Impact of Pyridyl Moieties on the Inhibitory Properties of Prominent Acyclic Metal Chelators Against Metallo-β-Lactamase-Producing Enterobacteriaceae: Investigating the