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Prof Dr. Charles Perrin | Chemistry and Materials Science | Best Researcher Award

 Professor at Distinguished Professor Emeritus of UCSD, United States

Professor Dr. Charles L. Perrin, born on July 22, 1938, in Pittsburgh, PA, is a distinguished professor emeritus at UC San Diego, where he has served since 1964. 🎓 He holds an A.B. summa cum laude in Chemistry from Harvard College (1959) and a Ph.D. in Organic Chemistry from Harvard University (1963). 💍 Married to Marilyn Heller Perrin, they have two sons. 👨‍👩‍👦‍👦 Dr. Perrin’s career is marked by numerous awards, including the Alfred P. Sloan Foundation Fellowship, the ACS James Flack Norris Award, and multiple teaching excellence awards at UCSD. 🏅 His research in physical-organic chemistry encompasses molecular structure, reaction mechanisms, NMR methods, and hydrogen bonding. 🧪 He has authored over 190 scientific articles and has made significant contributions, such as the synthesis of malonic anhydrides and elucidating proton exchange mechanisms in amides. 📚 Dr. Perrin has also served as a consultant, expert witness, and editorial board member, and has chaired and organized various scientific conferences. 🌍🔬

Professional Profile:

Education🎓

Professor Dr. Charles L. Perrin’s education is rooted in his outstanding academic achievements. 🎓 He graduated summa cum laude with an A.B. in Chemistry from Harvard College in 1959. 🏛️ He then pursued a Ph.D. in Organic Chemistry under the guidance of Frank H. Westheimer at Harvard University, completing it in 1963. 📜 Following his doctorate, he was awarded an NSF Post-Doctoral Fellowship to work with Andrew Streitwieser, Jr., at the University of California, Berkeley, further solidifying his expertise in the field. 🔬

 

Professional Experience 📚

Professor Dr. Charles L. Perrin has had a distinguished professional career at UC San Diego, where he began as an Assistant Professor of Chemistry in 1964. 👨‍🏫 He was promoted to Associate Professor in 1971 and became a full Professor in 1980. 🌟 In 2018, he was honored as a Distinguished Professor Emeritus and was recalled to active service. 🎓 Over the decades, he has made significant contributions to physical-organic chemistry, published over 190 scientific articles, and received numerous prestigious awards. 🏅 Dr. Perrin has also served as a consultant, expert witness, and member of several editorial boards, and has chaired and organized key scientific conferences, solidifying his reputation as a leading figure in his field. 🌍

Research Interest 🔍

Professor Dr. Charles L. Perrin’s research interests lie in the realm of physical-organic chemistry, focusing on the molecular structure and mechanisms of organic reactions. 🧪 His work includes the study of malonic anhydrides, NMR methods for chemical kinetics, and proton exchange kinetics in amides and related compounds. 🔄 He delves into solvation and hydrogen bonding, stereoelectronic control in the cleavage of tetrahedral intermediates and acyl shifts, as well as kinetic and equilibrium isotope effects. 🔬 Dr. Perrin also explores the symmetry of hydrogen bonds, anomeric effects, conformational analysis, and steric hindrance to ionic solvation, alongside nonradical reactions of p-benzyne diradicals and the chemistry of resulting “naked” aryl anions. 🌐 🧬💻

Award and Honor🌟 

Professor Dr. Charles L. Perrin has received numerous awards and honors throughout his distinguished career. 🏅 He was elected to Phi Beta Kappa at Harvard College in 1958 and received an Alfred P. Sloan Foundation Fellowship in 1967-69. 🌟 He was honored with a Special HEW Research Fellowship at Göteborgs Universitet in Sweden (1972-73) and was named a Fellow of the American Association for the Advancement of Science in 1984. 🔬 Dr. Perrin has been recognized for his teaching excellence with multiple awards from UCSD, including the Revelle College Excellence in Teaching Awards (1977, 1993) and the UCSD Chancellor’s Associates’ Faculty Excellence Award for Teaching in 2001. 🎓 He received the prestigious ACS James Flack Norris Award in Physical Organic Chemistry in 2015 and was named the Distinguished Scientist Award of the ACS San Diego Section in 2017. 🌍 Additionally, he has held various visiting professorships and lectureships worldwide, further cementing his status as a leading figure in his field. 🌐

 

Research Skills 🔬 

Professor Dr. Charles L. Perrin possesses exceptional research skills in physical-organic chemistry. 🧪 He is adept at utilizing NMR methods for chemical kinetics and developing innovative techniques such as variable-temperature NMR and magnetization-transfer and 2D-NMR methods for multisite kinetics. 🔄 His expertise includes synthesizing complex molecules like malonic anhydrides and elucidating reaction mechanisms at the molecular level. 🔬 Dr. Perrin has a keen ability to investigate proton exchange kinetics, solvation, hydrogen bonding, and stereoelectronic effects, making significant contributions to understanding the fundamental principles governing organic reactions. 🌟 His work also includes the application of isotopic perturbation and kinetic isotope effects, showcasing his comprehensive analytical and experimental capabilities. 🌐

 

Achievements 🏅 🏆

Professor Dr. Charles L. Perrin has made numerous groundbreaking achievements in physical-organic chemistry. 🧪 He recognized the generality of ipso substitution and introduced the related terminology. 📚 He authored the textbook “Mathematics for Chemists” and ACS Audio Courses on “Probability and Statistics for Chemists” and “Calculus for Chemists.” 🔬 His work elucidated the mechanisms of proton exchange in amides, peptides, and proteins, and he synthesized malonic anhydrides, classic molecules sought for 70 years. 🔄 Dr. Perrin developed innovative NMR methods, discovered a chain mechanism for proton exchange, and made significant advancements in understanding the Curtin-Hammett Principle. 🌐 He critically assessed stereoelectronic control, evaluated the anomeric effect, and measured the rate of NH4+ rotation within its solvent cage. 🔍 His research demonstrated the nonexistence of the reverse anomeric effect, elucidated the symmetry of hydrogen bonds, and developed an accurate NMR titration method. 🌟 He also discovered new reactions involving p-benzyne and demonstrated nonadditivity of secondary deuterium isotope effects on basicities.

 

Publications📖📚

Symmetry of Hydrogen Bonds: Application of NMR Method of Isotopic Perturbation and Relevance of Solvatomers

  • Publication: Molecules, 2023, 28(11), 4462 📄
  • Author: Perrin, C.L.
  • Citations: 1 🔬

My First Publication

  • Publication: Journal of Physical Or
  • ganic Chemistry, 2022, 35(11), e4302 📄
  • Author: Perrin, C.L.
  • Citations: 0 🚫

The Complete Mechanism of an Aldol Condensation in Water

  • Publication: Physical Chemistry Chemical Physics, 2022, 24(31), pp. 18978–18982 📄
  • Authors: Perrin, C.L., Kim, J.
  • Citations: 1 🔬

Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics

  • Publication: ACS Omega, 2022, 7(26), pp. 22930–22937 📄
  • Authors: Shrinidhi, A., Perrin, C.L.
  • Citations: 2 🔬🔬

Malonic Anhydrides, Challenges from a Simple Structure

  • Publication: Journal of Organic Chemistry, 2022, 87(11), pp. 7006–7012 📄
  • Author: Perrin, C.L.
  • Citations: 0 🚫

Glossary of Terms Used in Physical Organic Chemistry (IUPAC Recommendations 2021)

  • Publication: Pure and Applied Chemistry, 2022, 94(4), pp. 353–534 📄
  • Authors: Perrin, C.L., Agranat, I., Bagno, A., Uggerud, E., Williams, I.H.
  • Citations: 19 🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬🔬

Ipso

  • Publication: Journal of Organic Chemistry, 2021, 86(21), pp. 14245–14249 📄
  • Author: Perrin, C.L.
  • Citations: 6 🔬🔬🔬🔬🔬🔬

Comment on “Topography of the Free Energy Landscape of Claisen-Schmidt Condensation: Solvent and Temperature Effects on the Rate-Controlling Step” by N. D. Coutinho, H. G. Machado, V. H. Carvalho-Silva and W. A. da Silva

  • Publication: Physical Chemistry Chemical Physics, 2021, 23(38), pp. 22199–22201 📄
  • Author: Perrin, C.L.
  • Citations: 1 🔬

Cyclohexeno[3,4]cyclodec-1,5-diyne-3-ene: A Convenient Enediyne

  • Publication: Organic Letters, 2021, 23(17), pp. 6911–6915 📄
  • Authors: Shrinidhi, A., Perrin, C.L.
  • Citations: 2 🔬🔬

Enthalpic and Entropic Contributions to the Basicity of Cycloalkylamines

  • Publication: Chemical Science, 2020, 11(32), pp. 8489–8494 📄
  • Authors: Perrin, C.L., Shrinidhi, A.
  • Citations: 3 🔬🔬🔬
Charles Perrin | Chemistry and Materials Science | Best Researcher Award

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