Dr. Emmanuel Mintah Bonku | Green Chemistry | Sustainable Chemistry Award

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Dr. Emmanuel Mintah Bonku | Green Chemistry | Sustainable Chemistry Award

Dr. Emmanuel Mintah Bonku , Shanghai Institute of Materia Medica, CAS , China

Emmanuel Mintah Bonku, PhD, is a dedicated postdoctoral researcher at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, specializing in green chemistry and sustainable drug development. With a Ph.D. in Medicinal Chemistry from the University of Chinese Academy of Sciences, his research focuses on synthetic methodologies for antiviral drugs, especially in emerging diseases like monkey pox. He developed a groundbreaking synthesis process for tecovirimat, which is undergoing registration in China. Emmanuel has also worked on the synthesis of cariprazine, benzimidazole compounds, and other pharmaceuticals. His achievements have earned him the Excellent International Graduate Award from the Chinese Academy of Sciences in 2024. Passionate about sustainability in the pharmaceutical sector, Emmanuel strives to inspire future generations of scientists with his innovative approach to drug development.

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Summary of Suitability for Award:

Emmanuel Mintah Bonku, PhD, is highly suitable for the “Sustainable Chemistry Award” based on his exceptional contributions to green and sustainable drug development, particularly in medicinal chemistry. His research focuses on the development of innovative and environmentally friendly synthetic methodologies, notably for antiviral and other life-saving drugs. He has demonstrated excellence in synthesizing antiviral drugs like tecovirimat for monkey pox, optimizing the production process for large-scale application with minimal environmental impact. Emmanuel Mintah Bonku has also worked on biotransformation techniques and green chemistry, striving to make pharmaceutical synthesis more sustainable. Emmanuel Mintah Bonku is an ideal candidate for the “Sustainable Chemistry Award” due to his groundbreaking work in green chemistry and sustainable pharmaceutical development. His innovative research and dedication to promoting sustainability in drug manufacturing make him a strong advocate for environmentally conscious chemistry practices.

🎓Education:

Emmanuel Mintah Bonku holds a Doctor of Philosophy (Ph.D.) in Medicinal Chemistry from the University of Chinese Academy of Sciences (2021-2024), focusing on green and sustainable drug development. He completed a Master of Engineering (M.Eg.) in Chemical Engineering and Technology from Wuhan University of Science and Technology (2018-2021), specializing in biotransformation and sustainable chemistry. Prior to that, he earned a Bachelor of Science (B.Sc.) in Environmental Science, with a focus on ethnobotany, from the University of Cape Coast, Ghana (2012-2017). In addition, Emmanuel holds a certificate in Information Communication and Technology (2012) from All Nations University College, Ghana. His academic background has equipped him with the technical expertise and interdisciplinary knowledge to make significant contributions to medicinal chemistry, particularly in the development of antiviral drugs and sustainable pharmaceutical processes.

🏢Work Experience:

Emmanuel Mintah Bonku is currently a postdoctoral researcher at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, specializing in sustainable drug development. During his doctoral research, he pioneered novel synthetic methodologies for antiviral drugs, contributing to the development of tecovirimat for monkeypox and cariprazine for schizophrenia. He has also worked extensively on the synthesis of benzimidazole compounds for antihypertensive and anthelmintic applications. In his earlier career, Emmanuel contributed to projects focused on biotransformation and sustainable chemistry while earning his Master’s degree at Wuhan University of Science and Technology. His experience spans academic research, guest reviewing for journals, and collaborative work with international experts in the field. Emmanuel’s role as a researcher involves advanced techniques in medicinal chemistry, drug synthesis, and process optimization, with an emphasis on green and sustainable practices.

🏅Awards: 

Emmanuel Mintah Bonku has been recognized for his outstanding contributions to medicinal chemistry, particularly in the synthesis of antiviral drugs. In 2024, he received the Excellent International Graduate Award from the Chinese Academy of Sciences in recognition of his innovative research on tecovirimat, a key antiviral drug for monkeypox. His achievements in sustainable drug development have positioned him as a leading figure in his field. Emmanuel has also contributed to various projects in the pharmaceutical industry and academia, promoting sustainability in drug development. His work has garnered attention and respect in the scientific community, and he continues to inspire others through his research, publications, and collaborations. As a guest reviewer for journals like Journal of Green Synthesis and Catalysis and Journal of Food Science, he is also recognized for his contributions to the scientific peer-review process. Emmanuel remains committed to advancing the field of green chemistry and pharmaceutical innovation.

🔬Research Focus:

Emmanuel Mintah Bonku’s research focuses on green and sustainable drug development, with a particular emphasis on the synthesis of antiviral drugs. His work is at the intersection of medicinal chemistry and sustainable chemistry, where he develops new synthetic methodologies for emerging infectious diseases, including monkeypox. Emmanuel pioneered a large-scale process for synthesizing tecovirimat, a critical antiviral drug, and has worked on the development of other pharmaceuticals like cariprazine for schizophrenia and benzimidazole compounds for antihypertensive and anthelmintic purposes. He is passionate about improving drug synthesis processes to make them more sustainable, focusing on minimizing environmental impact while maintaining high efficiency and effectiveness. His research also includes process optimization, such as using reactive distillation for drug synthesis. Emmanuel’s work aims to address current challenges in the pharmaceutical industry, particularly the need for greener, more efficient production methods for critical drugs in the global healthcare landscape.

Publication Top Notes:

1. Extraction of Essential Oil from Citrus reticulate Blanco Peel and Its Antibacterial Activity Against Cutibacterium acnes (Formerly Propionibacterium acnes)

Authors: HS Hou, EM Bonku, R Zhai, R Zeng, YL Hou, ZH Yang, C Quan

Year: 2019

Citations: 90

Journal: Heliyon 5(12)

2. An Alkali-Tolerant Carbonyl Reductase from Bacillus subtilis by Gene Mining: Identification and Application

Authors: W Luo, HJ Du, EM Bonku, YL Hou, LL Li, XQ Wang, ZH Yang

Year: 2019

Citations: 8

Journal: Catalysis Letters 149, 2973–2983

3. Extraction of Essential Oil from Citrus reticulate Blanco Peel and Its Antibacterial Activity Against Cutibacterium acnes (Formerly Propionibacterium acnes)

Authors: HS Hou, EM Bonku, R Zhai, R Zeng, YL Hou, ZH Yang, C Quan

Year: 2019

Citations: 7

Journal: Heliyon 5, E02

4. Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization

Authors: H Qin, A Odilov, EM Bonku, F Zhu, T Hu, H Liu, HA Aisa, J Shen

Year: 2022

Citations: 6

Journal: ACS Omega 7(49), 45678–45687

5. Efficient Large-Scale Process for Tecovirimat via Reactive Distillation for the Preparation of Cycloheptatriene

Authors: EM Bonku, H Qin, A Odilov, F Yang, X Xing, X Wang, SD Guma, J Shen

Year: 2023

Citations: 5

Journal: Organic Process Research & Development 27(11), 1984–1991

6. Synergistic Effect and Structure–Property of Bio-Based 1, 6-Hexanediol on Thermal, Mechanical, and Degradation Properties of Biopolymers

Authors: WMK Siegu, LDW Djouonkep, NBS Selabi, EM Bonku, Z Cheng, …

Year: 2023

Citations: 5

Journal: Journal of Polymers and the Environment 31(3), 1144–1159

7. Extraction of Essential Oil from Citrus reticulate

Authors: HS Hou, EM Bonku, R Zhai, R Zeng, YL Hou, ZH Yang, C Quan

Year: 2019

Citations: 5

Journal: Not listed

8. Establishment of a Propolis Ethanolic Extract Self-Microemulsifying Drug Delivery System and Its Antibacterial Activity

Authors: TC Wang, B Appiah, EM Bonku, ZH Yang, L Luo

Year: 2021

Citations: 4

Journal: Biocatalysis and Agricultural Biotechnology 31, 101905

9. Improved and Ligand-Free Copper-Catalyzed Cyclization for an Efficient Synthesis of Benzimidazoles from o-Bromoarylamine and Nitriles

Authors: EM Bonku, H Qin, A Odilov, S Abduahadi, SD Guma, F Yang, F Zhu, …

Year: 2024

Citations: 3

Journal: RSC Advances 14(10), 6906–6916

10. Impurity Study of Tecovirimat

Authors: EM Bonku, H Qin, A Odilov, S Abduahadi, SD Guma, F Yang, X Xing, …

Year: 2024

Citations: 1

Journal: Heliyon 10(9)

 

 

 

 

 

György Keglevich | Green Chemistry | Green Chemistry Award

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Prof Dr. György Keglevich | Green Chemistry | Green Chemistry Award

 Professor at Dept of Organic Chemistry and Technology, Budapest University of Technology and Economics, Hungary

György Keglevich is a distinguished chemist specializing in organophosphorus chemistry. He is a Full Professor at the Department of Organic Chemistry and Technology at Budapest University of Technology and Economics. With a career spanning several decades, Keglevich has made significant contributions to the field through his research, publications, and mentoring of future scientists. His work encompasses a wide range of topics in chemical synthesis, green chemistry, and practical applications of his research.

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György Keglevich is a prominent researcher affiliated with the Budapest University of Technology and Economics in Budapest, Hungary. He has made significant contributions to the field, with a notable citation count of 9,463 across 590 documents. His h-index is 43, reflecting the impact and influence of his work in the academic community.

Education

Keglevich graduated from the Technical University of Budapest (TUB) in 1981 with a degree in chemical engineering. He obtained his PhD and Doctor of Chemical Science degrees in organophosphorus chemistry and earned his “Dr Habil.” degree in 1995. His early academic career included research at Duke University under the guidance of Professor Louis D. Quin.

Research Focus

Keglevich’s research primarily revolves around organophosphorus chemistry, including the development of P-heterocyclic compounds, ring enlargement of five-membered P-heterocycles, and the synthesis of bridged P-heterocycles. His work also explores the reactivity of aromatic phospholes, phosphine-transition metal complexes, and green chemistry practices such as microwave-assisted reactions and the use of ionic liquids.

Professional Journey

Keglevich began his career as a research employee at the Chinoin Pharmaceutical Factory before joining TUB’s Department of Organic Chemical Technology as an Assistant Professor in 1982. He was promoted to Associate Professor in 1993 and became a Full Professor in 1996. He has held leadership roles within his department, including serving as Head from 1999 to 2021. He has also been a Visiting Associate Professor at the University of Massachusetts on multiple occasions.

Honors & Awards

Keglevich has received several prestigious awards, including the Award of the Hungarian Academy of Sciences in 2004. In 2021, he was honored with the state decoration of Knight-Cross for Hungarian Order, and in 2022, he received the József Palatine Prize from Budapest University of Technology. These accolades recognize his significant contributions to the field of chemistry.

Publications Noted & Contributions

Keglevich has made substantial contributions through his publications, which include around 651 papers, 51 book chapters, and two books. His research is noted for advancements in the Hirao reaction, catalyst-free P–C coupling reactions, and microwave-assisted direct esterification. His contributions have been influential in developing new methods and applications in chemistry.

N-Functionalization of β-Aminophosphonates: Cytotoxic Effects of the New Derivatives

Journal: Organic & Biomolecular Chemistry

Year: 2024

DOI: 10.1039/D4OB00243A

Contributors: György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Oláhné Szabó Rita, László Drahos, Konstantin Karaghiosoff

Synthesis of Mesylated and Tosylated α-Hydroxy-Benzylphosphonates; Their Reactivity and Cytostatic Activity

Journal: ACS Omega

Date: July 16, 2024

DOI: 10.1021/acsomega.4c04382

Contributors: Zsuzsanna Szalai, Márton Debrei, Péter Ábrányi-Balogh, Szilvia Bősze, Rita Oláhné Szabó, Konstantin Karaghiosoff, László Drahos, György Keglevich

Microwave-Assisted, Ionic Liquid-Catalyzed Aminolysis and Alcoholysis of Phosphinic Derivatives: The Interconversion of Phosphinates and Phosphinic Amides

Journal: Green Chemistry

Year: 2023

DOI: 10.1039/D3GC02711B

Contributors: György Keglevich, Nikoletta Harsági, Sarolta Szilágyi

New N-Acyl- as well as N-Phosphonoylmethyl- and N-Phosphinoylmethyl-α-Amino-Benzylphosphonates by Acylation and a Tandem Kabachnik–Fields Protocol

Journal: Organic & Biomolecular Chemistry

Year: 2023

DOI: 10.1039/D3OB00010A

Contributors: Petra Regina Varga, Konstantin Karaghiosoff, Éva Viktória Sári, András Simon, László Hegedűs, László Drahos, György Keglevich

Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction

Journal: Chemistry – A European Journal

Date: December 6, 2023

DOI: 10.1002/chem.202302465

Contributors: Bianka Huszár, Renáta Szolga, Szilvia Bősze, Rita Oláhné Szabó, András Simon, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos, György Keglevich

Research Timeline

Keglevich’s research career began in the early 1980s with a focus on chemical synthesis and organophosphorus chemistry. Over the decades, he has developed and refined methodologies in green chemistry and practical applications. His research timeline includes significant milestones such as his promotion to Full Professor in 1996 and his ongoing work in innovative chemistry practices.

Collaborations and Projects

Keglevich has collaborated on numerous projects related to organophosphorus chemistry and green chemistry. His industrial projects include the synthesis of pharmaceutical intermediates and products, which are reflected in his three patents. He has also engaged in various academic collaborations, contributing to advancements in both theoretical and practical aspects of chemistry.

György Keglevich has authored or co-authored approximately 651 papers, including 51 book chapters and two books. His research output has earned him an h-index of 48, reflecting his significant impact in the field of chemistry. His publications are highly regarded, indicating a strong influence in organophosphorus and green chemistry research.

Strengths of the Green Chemistry Award for Prof. Dr. György Keglevich

  1. Significant Contributions to Green Chemistry: Prof. Keglevich’s research emphasizes green chemistry practices, including microwave-assisted reactions and the use of ionic liquids. These contributions align well with the principles of green chemistry, aiming to make chemical processes more sustainable and environmentally friendly.
  2. Innovative Methodologies: His work on catalyst-free P–C coupling reactions, microwave-assisted esterification, and ionic liquid-catalyzed reactions demonstrates a commitment to developing new, more efficient, and eco-friendly chemical processes.
  3. Extensive Publication Record: With over 651 papers and numerous contributions to high-impact journals, Prof. Keglevich’s extensive publication record showcases his deep engagement with and impact on the field of green chemistry.
  4. High Citation Count: An h-index of 48 and a citation count of 9,463 indicate that his research is highly influential and well-regarded within the academic community. This metric underscores the relevance and importance of his work in advancing green chemistry.
  5. Recognition and Awards: The numerous awards and honors, including the Knight-Cross for Hungarian Order and the József Palatine Prize, affirm his significant impact and contributions to chemistry, reinforcing his candidacy for the Green Chemistry Award.

Areas for Improvement

  1. Broader Impact on Industry: While Prof. Keglevich’s research is highly influential academically, showcasing a broader impact on industrial applications could strengthen his case for the Green Chemistry Award. Highlighting how his methodologies have been adopted or commercialized would be beneficial.
  2. Integration with Emerging Green Technologies: There could be a more explicit connection to emerging green technologies such as renewable energy solutions or advanced recycling methods. Emphasizing how his work integrates with or contributes to these areas might enhance his profile.
  3. Interdisciplinary Collaborations: Expanding collaborations beyond organophosphorus chemistry to include other disciplines such as materials science or environmental engineering could demonstrate a more comprehensive approach to solving green chemistry challenges.
  4. Public Engagement and Outreach: Increasing efforts in public engagement, science communication, and education could further highlight the societal impact of his research. Showcasing initiatives that aim to educate and inspire the next generation of chemists could add value.
  5. Future Research Directions: Outlining specific future research directions and how they align with the evolving goals of green chemistry could provide a forward-looking perspective. This might include exploring new green solvents, reaction conditions, or sustainable practices.

Conclusion

Prof. Dr. György Keglevich is a leading figure in green chemistry with a distinguished record of innovative research, extensive publications, and significant contributions to sustainable chemical practices. His work on eco-friendly methodologies and high-impact research underscores his qualifications for the Green Chemistry Award. Addressing areas for improvement, such as demonstrating broader industrial impact and engaging with emerging green technologies, could further strengthen his candidacy. Overall, his accomplishments and recognition in the field make him a strong contender for the award, reflecting his dedication to advancing green chemistry and its practical applications.