Dr. Xufen Yu | Medicinal Chemistry | Best Researcher Award

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Dr. Xufen Yu | Medicinal Chemistry | Best Researcher Award

Dr. Xufen Yu | Medicinal Chemistry | Associate Professor at Fudan University, China

Dr. Xufen Yu is an Associate Professor in the Department of Medicinal Chemistry at Fudan University’s School of Pharmacy. She specializes in drug discovery, chemical biology, and targeted protein degradation, particularly in cancer therapeutics. Before joining Fudan University, she was an Instructor and Postdoctoral Fellow at the Icahn School of Medicine at Mount Sinai, where she contributed significantly to pharmacological sciences. Dr. Yu has also held postdoctoral positions at Purdue University and the University of Hawaii at Hilo. She holds a Ph.D. from the Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry. Her research has led to numerous high-impact publications in journals such as Journal of Medicinal Chemistry, Oncogene, and Nature Cancer. With extensive expertise in PROTAC-based therapeutics and epigenetic regulation, Dr. Yu continues to make significant contributions to the field of medicinal chemistry and targeted cancer therapy.

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Summary of Suitability for Award:

Dr. Xufen Yu is an exceptionally accomplished researcher in medicinal chemistry, with significant contributions to drug discovery, targeted protein degradation, and epigenetics. Her extensive academic background, including a Ph.D. from the Chinese Academy of Sciences and postdoctoral research at prestigious institutions such as Purdue University and the Icahn School of Medicine at Mount Sinai, demonstrates her expertise in chemical biology and small-molecule therapeutics. She has consistently advanced the field through high-impact publications, innovative research, and groundbreaking discoveries in PROTACs and DUBTACs, which have transformed targeted cancer therapy.  Given her outstanding achievements, innovative research, and contributions to medicinal chemistry, Dr. Xufen Yu is highly suitable for the “Best Researcher Award”. Her pioneering work in targeted protein degradation, combined with her international recognition and research excellence, makes her a strong candidate. Her research has not only advanced scientific knowledge but also holds significant promise for therapeutic applications, reinforcing her eligibility for this distinguished honor.

🎓Education:

Dr. Xufen Yu earned her Ph.D. in Organic Chemistry from the Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, in 2011. Her doctoral research focused on synthetic organic chemistry and drug discovery. Prior to that, she completed her undergraduate studies at Anhui University, Hefei, China, earning a Bachelor’s degree in Chemistry in 2006. With a strong academic foundation, Dr. Yu developed expertise in medicinal chemistry, chemical biology, and targeted protein degradation. Her educational journey equipped her with extensive knowledge of molecular design, synthetic methodologies, and structure-activity relationship studies, laying the groundwork for her future contributions to pharmacological sciences. Her rigorous training in organic synthesis and chemical biology has driven her impactful research in developing novel therapeutics, particularly in targeted protein degradation and epigenetic regulation.

🏢Work Experience:

Dr. Xufen Yu has had a distinguished career in academia and research, with extensive postdoctoral and faculty experience. She is currently an Associate Professor in the Department of Medicinal Chemistry at Fudan University, Shanghai, China. Before joining Fudan, she was an Instructor in the Department of Pharmacological Science at the Icahn School of Medicine at Mount Sinai, New York (2021–2022), following a postdoctoral fellowship at the same institution from 2017 to 2020. She also worked as a postdoctoral fellow in Chemistry at Purdue University (2013–2014) and in Pharmaceutical Science at the University of Hawaii at Hilo (2011–2013). Through these roles, she has contributed significantly to medicinal chemistry, focusing on drug discovery, targeted protein degradation, and cancer therapeutics. Her work across multiple prestigious institutions reflects her expertise in interdisciplinary research, integrating chemistry and pharmacology to develop novel small-molecule therapeutics.

🏅Awards: 

Dr. Xufen Yu has been recognized for her outstanding contributions to medicinal chemistry and drug discovery. She has received multiple awards and research grants for her pioneering work in targeted protein degradation and epigenetics. Her innovative research has been acknowledged with prestigious fellowships and funding from institutions such as the National Institutes of Health (NIH) and the Chinese Academy of Sciences. Additionally, she has been honored for her significant publications in high-impact journals, receiving accolades for breakthrough studies on PROTACs and epigenetic regulators in cancer therapy. Her commitment to scientific excellence has led to invitations as a speaker at international conferences, where she has shared her expertise in medicinal chemistry. Dr. Yu’s contributions have been instrumental in advancing chemical biology and therapeutic discovery, making her a well-respected figure in her field.

🔬Research Focus:

Dr. Xufen Yu’s research focuses on the development of novel therapeutic strategies targeting disease-related proteins, particularly in cancer and metabolic disorders. Her expertise lies in targeted protein degradation, including the design and synthesis of PROTACs (Proteolysis Targeting Chimeras) and DUBTACs (Deubiquitinase Targeting Chimeras). She has explored epigenetic regulation in cancer therapy, investigating how small molecules can modulate oncogenic transcription factors and chromatin regulators. Her work also includes studying the role of ubiquitin-proteasome and autophagy systems in disease mechanisms, aiming to develop highly selective small-molecule therapeutics. Through interdisciplinary approaches combining medicinal chemistry, chemical biology, and pharmacology, she has contributed to advancing targeted cancer treatments. Dr. Yu’s research has led to the discovery of several potent and selective degraders for oncogenic proteins such as EZH2, WDR5, and USP7, paving the way for new treatment modalities in oncology.

Publication Top Notes:

Macrocyclic drugs and synthetic methodologies toward macrocycles
Authors: X Yu, D Sun
Citations: 276
Year: 2013

Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism
Authors: AJ Bott, J Shen, C Tonelli, L Zhan, N Sivaram, YP Jiang, X Yu, V Bhatt, …
Citations: 155
Year: 2019

Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders
Authors: M Cheng, X Yu, K Lu, L Xie, L Wang, F Meng, X Han, X Chen, J Liu, …
Citations: 151
Year: 2020

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Authors: J Wang, X Yu, W Gong, X Liu, KS Park, A Ma, YH Tsai, Y Shen, T Onikubo, …
Citations: 134
Year: 2022

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
Authors: X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, …
Citations: 103
Year: 2021

Discovery of first-in-class protein arginine methyltransferase 5 (PRMT5) degraders
Authors: Y Shen, G Gao, X Yu, H Kim, L Wang, L Xie, M Schwarz, X Chen, …
Citations: 84
Year: 2020

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery
Authors: AM Chiarella, KV Butler, BE Gryder, D Lu, TA Wang, X Yu, S Pomella, …
Citations: 77
Year: 2020

Cationic Palladium Complex Catalyzed Diastereo-and Enantioselective Tandem Annulation of 2-Formylarylboronic Acids with Allenoates
Authors: X Yu, X Lu
Citations: 57
Year: 2009

AKT degradation selectively inhibits the growth of PI3K/PTEN pathway–mutant cancers with wild-type KRAS and BRAF by destabilizing aurora kinase B
Authors: J Xu, X Yu, TC Martin, A Bansal, K Cheung, A Lubin, E Stratikopoulos, …
Citations: 51
Year: 2021

Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders
Authors: X Yu, J Xu, L Xie, L Wang, Y Shen, KM Cahuzac, X Chen, J Liu …
Citations: 42
Year: 2021

Assist. Prof. Dr. Nitin Srivastava | Medicinal Chemistry | Best Researcher Award

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Assist. Prof. Dr. Nitin Srivastava | Medicinal Chemistry | Best Researcher Award

Assist. Prof. Dr. Nitin Srivastava , Amity University Uttar Pradesh Lucknow Campus , India

Dr. Nitin Srivastava is a distinguished Assistant Professor (Senior-most Grade) in the Department of Chemistry at Amity University Uttar Pradesh, Lucknow Campus. With over 16 years of teaching and research experience, he specializes in diverse fields such as engineering chemistry, physical chemistry, and quantum chemistry. Dr. Srivastava is a prolific researcher, focusing on organosulfur compounds with significant biological applications, including anticancer and antimicrobial activities. His innovative work emphasizes cleaner, greener, and cost-effective synthetic methods. Dr. Srivastava is also an accomplished author, having penned the book Environment & We for UPSC aspirants. His academic journey, coupled with his dedication to sustainable chemistry, has earned him multiple accolades, including the Young Scientist Award and the CV Raman Prize.

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Summary of Suitability for Award:

Dr. Nitin Srivastava is an exceptional candidate for the “Best Researcher Awards,” given his prolific contributions to chemical research, particularly in sustainable and medicinal organosulfur chemistry. With over 16 years of experience in academia and research, he has demonstrated excellence in teaching, mentoring, and groundbreaking studies. His innovative work on carbon disulfide-mediated synthesis of bioactive compounds has resulted in eco-friendly and cost-effective methods for producing trithio carbonates, rhodanine derivatives, and thioureas, all of which show significant anticancer, antimicrobial, and anti-plasmodial activities. Dr. Nitin Srivastava’s consistent academic output, focus on sustainability, and ability to translate research into real-world applications make him an exemplary candidate for the “Best Researcher Awards.” His groundbreaking methodologies and commitment to environmentally friendly chemical synthesis stand out as significant achievements that resonate with the award’s purpose of honoring excellence and innovation in research.

🎓Education:

Dr. Nitin Srivastava earned his Ph.D. in Chemistry from Amity University Uttar Pradesh, focusing on carbon disulfide-mediated synthesis of biologically potent organosulfur scaffolds. His research emphasized the development of cleaner and greener synthetic methods for compounds with significant biological applications. He holds an M.Sc. in Physical Chemistry from the University of Lucknow (2001), where he graduated with First Division. Additionally, he cleared the CSIR-UGC NET exam twice (Dec 2002 & June 2003), reflecting his strong academic foundation. Dr. Srivastava’s educational journey is marked by a passion for sustainability and innovation in chemical sciences, laying the groundwork for his impactful teaching and research career.

🏢Work Experience:

Dr. Nitin Srivastava has over 16 years of teaching and research experience at renowned institutions. Since 2008, he has served as an Assistant Professor in the Department of Chemistry at Amity University Uttar Pradesh, where he teaches courses like quantum chemistry, instrumental analysis, and environmental studies. He also worked as a Lecturer at National P.G. College, Lucknow (2005–2008), focusing on solid-state and physical chemistry. His contributions extend beyond teaching, with a strong emphasis on research in sustainable organosulfur chemistry. Dr. Srivastava’s extensive experience has positioned him as a key educator and researcher in his field, influencing both students and the scientific community.

🏅Awards: 

Dr. Nitin Srivastava has been recognized for his outstanding contributions to chemical sciences. He received the Young Scientist Award (2022) from the International Academy of Science and Research, Kolkata, acknowledging his pioneering work in sustainable chemistry. In 2023, he was awarded the prestigious CV Raman Prize by the Institute of Researchers, highlighting his innovative research on organosulfur compounds. These accolades reflect his dedication to advancing sustainable chemical practices and his impactful contributions to academia and research.

🔬Research Focus:

Dr. Nitin Srivastava specializes in organosulfur chemistry, developing greener and cost-effective synthetic methods for compounds like trithio carbonates, thioureas, and rhodanine derivatives. His research emphasizes sustainability, using phase transfer catalysts to create bioactive molecules with significant medicinal applications. These compounds have demonstrated anticancer activity against cell lines like HeLa and U87-MG and antimicrobial and anti-plasmodial properties. Dr. Srivastava’s work bridges the gap between sustainable chemistry and practical applications in medicine, agriculture, and industry, contributing to global efforts in creating environmentally friendly chemical processes.

Publication Top Notes:

Effect of dopant solubility and excess doping on the superconducting properties of doped Nb₃Sn prepared by field-assisted sintering technique
Authors: Srivastava, N., Matthews, G.A.B., Liu, J., Grovenor, C.R.M., Santra, S.
Year: 2024
Citations: 0

A Novel and Easy Synthesis of 1H-Tetrazoles employing p-Toluenesulfonyl azide
Authors: Vithal, R.A., Ram, K., Chundawat, N.S., Nitin, S., Pal, S.G.
Year: 2024
Citations: 0

Novel thiosemicarbazone based sensors for transition metals
Authors: Vithal, R.A., Kishore, R., Janardan, D.S., Srivastava, N., Singh, G.P.
Year: 2024
Citations: 0

Synthesis and anticancer screening of substituted (phenyl)-1-((naphthalen-5-yl)methylene)thiosemicarbazide against PC3 prostate cancer cells
Authors: Anisree, S., Shanmugavelan, P., Palanisamy, S., Kishore, R., Srivastava, N.
Year: 2024
Citations: 0

Production of fatty acids from distilled aromatic waste biomass using oleaginous yeast
Authors: Singh, S., Chaturvedi, S., Syed, N., Khare, S.K., Rout, P.K.
Year: 2024
Citations: 1

Terminal-substituted benzoxazole based Schiff-base Mesogens and their Cu(II) complexes: Synthesis and structural characterization
Authors: Dubey, R., Pandey, J., Srivastava, N.
Year: 2024
Citations: 0

A novel bulk (Nb,Zr,Pt)67Ti33 high-entropy alloy superconductor: synthesis and structure-property relationship
Authors: Srivastava, N., Santra, S.
Year: 2024
Citations: 0

Improved production of alkaline and solvent-stable proteases from a halotolerant Exiguobacterium isolate through heterologous expression
Authors: Srivastava, N., Shiburaj, S., Khare, S.K.
Year: 2024
Citations: 4

Microwave-Assisted Phase Transfer Catalytic Synthesis of Aryl Benzothiazole Derivatives and Their Anticancer Screening
Authors: Yadav, S., Kishore, R., Srivastava, N.
Year: 2024
Citations: 1

Cleaner, Greener Synthesis and Anticancer Screening of Asymmetrical Trithiocarbonates
Authors: Srivastava, N., Chaturvedi, D., Kishore, R., Kaur, M., Kalia, N.
Year: 2024
Citations: 0

 

 

 

 

 

Asmaa Hamouda | Medicinal Chemistry | Best Researcher Award

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Dr. Asmaa Hamouda | Medicinal Chemistry | Best Researcher Award

Doctorate at Alexandria University, Egypt

Asmaa F. Hamouda is an accomplished biochemist with over a decade of experience in teaching and research, focusing on medical biochemistry and lifestyle-related disorders. A breast cancer survivor, she is deeply committed to patient education and support, particularly in disease management. Based in Egypt, Asmaa has authored 25 books and published 30 scientific papers, making significant contributions to her field. Her diverse experiences include roles at prestigious universities and clinical settings.

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Asmaa has achieved considerable recognition in the academic community, evidenced by a robust citation record on platforms such as Google Scholar. Her research impact is reflected in her numerous publications and her active engagement in scientific discourse, highlighting the significance of her contributions to biochemistry and nutrition.

  • Citations: 48
  • Documents: 7
  • h-index: 4

Education

Asmaa holds a PhD in Biochemistry from Alexandria University, earned in January 2013, where she graduated with distinction. She also completed her Master’s degree in Biochemistry in October 2007 and her Bachelor of Science in Biochemistry/Chemistry in May 2003, both from the same institution. In 2021, she further enhanced her expertise by obtaining a professional certification in Functional Medicine and Nutrition.

Research Focus

Her research primarily investigates the biochemical mechanisms underlying lifestyle diseases and the role of nutrition in health management. Asmaa is particularly interested in exploring natural compounds for disease prevention and treatment, aiming to bridge the gap between biochemistry and practical health solutions.

Professional Journey

Asmaa began her career as a demonstrator at Alexandria University, gradually advancing to positions such as lecturer and assistant professor at universities in Saudi Arabia. Currently, she serves as a nutrition advisor, leveraging her academic expertise to support patients in managing their health through tailored nutritional strategies.

Honors & Awards

Throughout her career, Asmaa has received numerous accolades for her contributions to teaching and research. Her work has been recognized at various international conferences, where she has been invited to speak and present, underscoring her influence and leadership in the field of biochemistry.

Publications Noted & Contributions

Asmaa has authored a variety of influential publications in reputable scientific journals, with key studies focusing on the biochemical effects of natural extracts. Her research on the therapeutic potential of compounds like pomegranate and avocado has drawn attention, showcasing innovative approaches to managing chronic diseases.

Investigating Grape Seed Extract as a Natural Antibacterial Agent for Water Disinfection in Saudi Arabia: A Pilot Chemical, Phytochemical, Heavy-Metal, Mineral, and CB-Dock Study Employing Water and Urine Samples

Identification of Effective Anti-HCV and Anti-HIV Royal Jelly Constituents and Their Acute Toxicity Evaluation in Albino Rats

  • Journal: Food and Chemical Toxicology
  • Date: 2023-12
  • DOI: 10.1016/j.fct.2023.114170
  • Contributors: Noha H. Habashy, Asmaa F. Hamouda, Marwa M. Abu Serie

A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

A Pilot Study of the Amelioration of Avocado Seed Oil in Obese Female Rats Induced by Carbon Tetrachloride and Alloxan Monohydrate

  • Journal: Journal of Drug and Alcohol Research
  • Date: 2022
  • Contributors: Asmaa Fathi Hamouda

 Research Timeline

Her research journey spans several significant projects, from her doctoral studies to her ongoing work as a nutrition advisor. Asmaa has consistently contributed to the academic literature, providing valuable insights into the role of biochemistry in health and disease management.

Collaborations and Projects

Asmaa has engaged in numerous collaborations with institutions and researchers across the globe. Her participation in international conferences has fostered partnerships in the fields of biochemistry and nutrition, enhancing the impact and reach of her research efforts.

Conclusion

Dr. Asmaa Hamouda exemplifies excellence in the field of medicinal chemistry and biochemistry. Her robust publication record, innovative research, and commitment to patient education highlight her as a leading figure in the academic community. While she has achieved significant recognition, focusing on collaboration, visibility, and public engagement can further enhance her impact. With her dedication and expertise, Asmaa is well-positioned to continue making meaningful contributions to health management and disease prevention.