Doctorate at Ravenshaw University, India
Dr. Sabita Nayak is the Head of the Department of Chemistry at Ravenshaw University, Cuttack, Odisha. With a rich academic background and extensive research experience, Dr. Nayak has made significant contributions to the field of chemistry, focusing on the synthesis of novel hybridized molecules and their biological activities.
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Scopus profile
Dr. Nayak has an impressive portfolio of over 49 publications in peer-reviewed journals, including high-impact journals such as ChemistrySelect, Bioorganic Chemistry, and Carbohydrate Research. Her work has been cited extensively, reflecting her significant impact in the field of chemical research
Education
Dr. Nayak earned her Ph.D. in Chemistry from Pune University in 2008, where she worked on the total synthesis of complex molecules. Her educational journey includes an M.Phil. in Chemistry from Utkal University, an M.Sc. in Chemistry from Ravenshaw University, and a B.Sc. in Chemistry from Utkal University.
Research Focus
Her research primarily explores the synthesis of small novel hybridized molecules, heterocyclic and carbocyclic molecules through Diels-Alder and Michael Addition Reactions, and carbohydrate sugar products. She is particularly interested in the biological activities of these synthesized molecules, contributing to advancements in medicinal chemistry.
Professional Journey
Dr. Nayak began her career as a Research Associate at Chembiotek Pharma Ltd. and later as a Postdoctoral Researcher at the University of Southwestern Medical Research Center, Dallas, Texas. Since 2010, she has been serving as an Assistant Professor in Chemistry at Ravenshaw University, where she continues to advance her research and teaching.
Honors & Awards
Dr. Nayak was awarded the “Dr. Mahamaya Pattnaik Smruti Samman” by Bigyan Prachar Samiti in 2022, recognizing her outstanding contributions to the field of chemistry.
Publications Noted & Contributions
Dr. Nayak’s notable publications include her research on [4+2]-cycloaddition reactions, thia-Michael addition-oxidation reactions, and the synthesis of 2H-chromene-based hydrazone derivatives. Her contributions have significantly advanced the understanding of synthetic methodologies and their applications in drug discovery.
Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights
Authors: Priyadarsini Mishra, Kumar Sahoo, Mohapatra, Nayak, Nath Kundu
Journal: Journal of Molecular Liquids
Year: 2024
Volume: 404
Page: 124967
Abstract: The study investigates the use of β-cyclodextrin (β-CD) encapsulation to enhance the therapeutic window of anticancer agents. Through a combination of experimental data and theoretical modeling, the research provides insights into how β-CD can improve the efficacy and reduce the side effects of anticancer drugs by modulating their release and bioavailability. The findings highlight the potential of β-CD as a valuable tool in drug delivery systems for cancer therapy.
New 2H-Chromene-Based Hydrazone Derivatives as Promising Anti-Breast Cancer Agents: Efficient Synthesis, Spectral Characterization, Molecular Docking, and ADMET Studies
Authors: Shankar Panda, Samanta, Sudha Ambadipudi, Nayak, Mohan Behera, Samanta
Journal: ChemistrySelect
Year: 2024
Volume: 9(15)
Article Number: e202400115
Abstract: This paper presents the synthesis of novel 2H-chromene-based hydrazone derivatives and their evaluation as potential anti-breast cancer agents. The study includes detailed spectral characterization, molecular docking studies, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis. The results suggest that these derivatives exhibit promising anti-cancer activity and could be developed into effective therapeutic agents for breast cancer treatment.
Transition-Metal Catalyzed [4+2]-Cycloaddition Reactions: A Sexennial Update
Authors: Panda, Mohapatra, Ansar Ahemad, Nayak, Mohapatra
Journal: ChemistrySelect
Year: 2024
Volume: 9(12)
Article Number: e202303643
Abstract: This review provides a comprehensive update on transition-metal catalyzed [4+2]-cycloaddition reactions over the past six years. It covers recent advances in reaction conditions, catalyst development, and applications in organic synthesis. The review highlights key developments and trends in the field, offering insights into how these reactions have evolved and their impact on synthetic chemistry.
Base Catalyzed One-Pot Thia-Michael Addition-Oxidation Reaction of Hetero-Aromatic Thiols to 2-Aryl-3-Nitro-2H-Chromenes and Their Antibacterial Evaluation
Authors: Samanta, Panda, Mohapatra, Bhattacharya, Sahoo
Journal: New Journal of Chemistry
Year: 2024
Volume: 48(11)
Pages: 4953–4959
Abstract: The article explores a base-catalyzed one-pot thia-Michael addition-oxidation reaction to synthesize 2-aryl-3-nitro-2H-chromenes from hetero-aromatic thiols. The synthesized compounds were evaluated for their antibacterial activity. The study demonstrates the efficiency of the proposed method in creating novel chromene derivatives with potential antimicrobial properties.
Palladium-Catalyzed Facile Synthesis of Imidazo[1,2-a]Pyridine-Flavone Hybrids and Evaluation of Their Antiplasmodial Activity
Authors: Raiguru, Panda, Mohapatra, Nayak
Journal: Journal of Molecular Structure
Year: 2023
Volume: 1294
Article Number: 136282
Abstract: This research presents a palladium-catalyzed approach for the synthesis of imidazo[1,2-a]pyridine-flavone hybrids. The study includes an evaluation of the antiplasmodial activity of these hybrids, highlighting their potential as new candidates for malaria treatment. The synthesis method is described as straightforward and efficient, offering a valuable addition to the development of antimalarial agents.
Research Timeline
Dr. Nayak’s research career began with her doctoral work at Pune University and has evolved through significant projects funded by agencies such as SERB, UGC, and CSIR. Her research timeline includes the completion of several projects and the initiation of ongoing studies in collaboration with esteemed institutions.
Collaborations and Projects
Dr. Nayak has collaborated with various researchers and institutions, including National Chemical Laboratory, Pune, and University of Southwestern Medical Research Center, Dallas. Her projects encompass a range of topics, from synthetic methodologies to biological evaluations, reflecting her broad expertise and collaborative approach in advancing chemical research.