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Dr. Sabita Nayak | Organic Synthesis | Best Researcher Award

Doctorate atĀ  Ravenshaw University, India

Dr. Sabita Nayak is the Head of the Department of Chemistry at Ravenshaw University, Cuttack, Odisha. With a rich academic background and extensive research experience, Dr. Nayak has made significant contributions to the field of chemistry, focusing on the synthesis of novel hybridized molecules and their biological activities.

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Scopus profile

Dr. Nayak has an impressive portfolio of over 49 publications in peer-reviewed journals, including high-impact journals such as ChemistrySelect, Bioorganic Chemistry, and Carbohydrate Research. Her work has been cited extensively, reflecting her significant impact in the field of chemical research

Education

Dr. Nayak earned her Ph.D. in Chemistry from Pune University in 2008, where she worked on the total synthesis of complex molecules. Her educational journey includes an M.Phil. in Chemistry from Utkal University, an M.Sc. in Chemistry from Ravenshaw University, and a B.Sc. in Chemistry from Utkal University.

Research Focus

Her research primarily explores the synthesis of small novel hybridized molecules, heterocyclic and carbocyclic molecules through Diels-Alder and Michael Addition Reactions, and carbohydrate sugar products. She is particularly interested in the biological activities of these synthesized molecules, contributing to advancements in medicinal chemistry.

Professional Journey

Dr. Nayak began her career as a Research Associate at Chembiotek Pharma Ltd. and later as a Postdoctoral Researcher at the University of Southwestern Medical Research Center, Dallas, Texas. Since 2010, she has been serving as an Assistant Professor in Chemistry at Ravenshaw University, where she continues to advance her research and teaching.

Honors & Awards

Dr. Nayak was awarded the “Dr. Mahamaya Pattnaik Smruti Samman” by Bigyan Prachar Samiti in 2022, recognizing her outstanding contributions to the field of chemistry.

Publications Noted & Contributions

Dr. Nayakā€™s notable publications include her research on [4+2]-cycloaddition reactions, thia-Michael addition-oxidation reactions, and the synthesis of 2H-chromene-based hydrazone derivatives. Her contributions have significantly advanced the understanding of synthetic methodologies and their applications in drug discovery.

Improving the therapeutic window of anticancer agents by Ī²-cyclodextrin encapsulation: Experimental and theoretical insights

Authors: Priyadarsini Mishra, Kumar Sahoo, Mohapatra, Nayak, Nath Kundu

Journal: Journal of Molecular Liquids

Year: 2024

Volume: 404

Page: 124967

Abstract: The study investigates the use of Ī²-cyclodextrin (Ī²-CD) encapsulation to enhance the therapeutic window of anticancer agents. Through a combination of experimental data and theoretical modeling, the research provides insights into how Ī²-CD can improve the efficacy and reduce the side effects of anticancer drugs by modulating their release and bioavailability. The findings highlight the potential of Ī²-CD as a valuable tool in drug delivery systems for cancer therapy.

New 2H-Chromene-Based Hydrazone Derivatives as Promising Anti-Breast Cancer Agents: Efficient Synthesis, Spectral Characterization, Molecular Docking, and ADMET Studies

Authors: Shankar Panda, Samanta, Sudha Ambadipudi, Nayak, Mohan Behera, Samanta

Journal: ChemistrySelect

Year: 2024

Volume: 9(15)

Article Number: e202400115

Abstract: This paper presents the synthesis of novel 2H-chromene-based hydrazone derivatives and their evaluation as potential anti-breast cancer agents. The study includes detailed spectral characterization, molecular docking studies, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis. The results suggest that these derivatives exhibit promising anti-cancer activity and could be developed into effective therapeutic agents for breast cancer treatment.

Transition-Metal Catalyzed [4+2]-Cycloaddition Reactions: A Sexennial Update

Authors: Panda, Mohapatra, Ansar Ahemad, Nayak, Mohapatra

Journal: ChemistrySelect

Year: 2024

Volume: 9(12)

Article Number: e202303643

Abstract: This review provides a comprehensive update on transition-metal catalyzed [4+2]-cycloaddition reactions over the past six years. It covers recent advances in reaction conditions, catalyst development, and applications in organic synthesis. The review highlights key developments and trends in the field, offering insights into how these reactions have evolved and their impact on synthetic chemistry.

Base Catalyzed One-Pot Thia-Michael Addition-Oxidation Reaction of Hetero-Aromatic Thiols to 2-Aryl-3-Nitro-2H-Chromenes and Their Antibacterial Evaluation

Authors: Samanta, Panda, Mohapatra, Bhattacharya, Sahoo

Journal: New Journal of Chemistry

Year: 2024

Volume: 48(11)

Pages: 4953ā€“4959

Abstract: The article explores a base-catalyzed one-pot thia-Michael addition-oxidation reaction to synthesize 2-aryl-3-nitro-2H-chromenes from hetero-aromatic thiols. The synthesized compounds were evaluated for their antibacterial activity. The study demonstrates the efficiency of the proposed method in creating novel chromene derivatives with potential antimicrobial properties.

Palladium-Catalyzed Facile Synthesis of Imidazo[1,2-a]Pyridine-Flavone Hybrids and Evaluation of Their Antiplasmodial Activity

Authors: Raiguru, Panda, Mohapatra, Nayak

Journal: Journal of Molecular Structure

Year: 2023

Volume: 1294

Article Number: 136282

Abstract: This research presents a palladium-catalyzed approach for the synthesis of imidazo[1,2-a]pyridine-flavone hybrids. The study includes an evaluation of the antiplasmodial activity of these hybrids, highlighting their potential as new candidates for malaria treatment. The synthesis method is described as straightforward and efficient, offering a valuable addition to the development of antimalarial agents.

Research Timeline

Dr. Nayak’s research career began with her doctoral work at Pune University and has evolved through significant projects funded by agencies such as SERB, UGC, and CSIR. Her research timeline includes the completion of several projects and the initiation of ongoing studies in collaboration with esteemed institutions.

Collaborations and Projects

Dr. Nayak has collaborated with various researchers and institutions, including National Chemical Laboratory, Pune, and University of Southwestern Medical Research Center, Dallas. Her projects encompass a range of topics, from synthetic methodologies to biological evaluations, reflecting her broad expertise and collaborative approach in advancing chemical research.

Sabita Nayak | Organic Synthesis | Best Researcher Award

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