Assoc Prof Dr. Athanassios Philippopoulos | Inorganic Chemistry | Best Researcher Award

Ruthenium <i>p</i>-Cymene Complexes Incorporating Substituted Pyridine–Quinoline-Based Ligands: Synthesis, Characterization, and Cytotoxic Properties

Publication Details:
Journal: Molecules
Date: July 2024
DOI: 10.3390/molecules29133215
Role: Author
Contributors: Afroditi Kokkosi, Elpida Garofallidou, Nikolaos Zacharopoulos, Nikolaos Tsoureas, Konstantina Diamanti, Nikolaos S. Thomaidis, Antigoni Cheilari, Christina Machalia, Evangelia Emmanouilidou, Athanassios Philippopoulos

This article explores the synthesis and characterization of ruthenium <i>p</i>-cymene complexes with substituted pyridine-quinoline ligands. It examines their potential cytotoxic properties, contributing to the field of metal-based anticancer agents.

Anti-Inflammatory and Antithrombotic Potential of Metal-Based Complexes and Porphyrins

Publication Details:
Journal: Compounds
Date: June 2024
DOI: 10.3390/compounds4020023
Role: Author
Contributors: Alexandros Tsoupras, Sofia Pafli, Charilaos Stylianoudakis, Kalliopi Ladomenou, C.A. Demopoulos, Athanassios Philippopoulos

This study evaluates the anti-inflammatory and antithrombotic activities of various metal-based complexes and porphyrins. The findings offer insights into their therapeutic potential for cardiovascular and inflammatory diseases.

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Publication Details:
Journal: Molecules
Date: October 2023
DOI: 10.3390/molecules28196899
Role: Author
Contributors: Antigoni Margariti, Vasiliki D. Papakonstantinou, George Stamatakis, C.A. Demopoulos, Christina Machalia, Evangelia Emmanouilidou, Gregor Schnakenburg, Maria-Christina Nika, Nikolaos S. Thomaidis, Athanassios Philippopoulos

The paper focuses on the cytotoxic effects and biological activities of first-row transition metal complexes with 2-(2′-pyridyl)quinoxaline ligands. It investigates their role as inflammatory mediators and their impact on platelet-activating factors and thrombin.

Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(<i>η</i>⁵-C₅R₅)Co{P(OEt)₂O}₃]⁻, (R = H, Me; Et = -C₂H₅) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Publication Details:
Journal: Molecules
Date: February 2023
DOI: 10.3390/molecules28041859
Role: Author
Contributors: Alexandros Kalampalidis, Artemis Damati, Demetrios Matthopoulos, Alexandros Tsoupras, C.A. Demopoulos, Gregor Schnakenburg, Athanassios Philippopoulos

This article investigates the cytotoxic properties and biological activities of tin(II) and tin(IV) complexes with oxygen tripodal ligands. It highlights their effectiveness as inhibitors of inflammatory mediators like PAF and thrombin.

Sterically Demanding Pyridine-Quinoline Anchoring Ligands as Building Blocks for Copper(<scp>i</scp>)-Based Dye-Sensitized Solar Cell (DSSC) Complexes

Publication Details:
Journal: Dalton Transactions
Date: 2022
DOI: 10.1039/d2dt02382b
Role: Author
Contributors: Anastasios Peppas, Demetrios Sokalis, Dorothea Perganti, Gregor Schnakenburg, Polycarpos Falaras, Athanassios Philippopoulos

This publication discusses the use of sterically demanding pyridine-quinoline ligands in designing copper(I)-based dye-sensitized solar cells. It contributes to the development of advanced materials for solar energy applications.

1. Significant Scholarly Impact: Philippopoulos has made notable contributions to the fields of organometallic and coordination chemistry, with over 1300 citations on Web of Science and 1520 on Google Scholar. This indicates a strong influence and recognition of his work within the scientific community.
2. Diverse Research Areas: His research spans several crucial areas, including renewable energy (dye-sensitized solar cells), bio-inorganic chemistry (metal-based drugs), and nanotechnologies. This broad focus demonstrates his versatility and impact across multiple subfields of chemistry.
3. High-Quality Publications: Philippopoulos has published over 50 peer-reviewed journal articles and contributed to significant research outputs, such as studies on ruthenium complexes, metal-based drugs, and copper(I)-based dye-sensitized solar cells. This reflects his commitment to advancing scientific knowledge and addressing pressing challenges.
4. Awards and Recognition: The recognition Philippopoulos has received, including the Best Researcher Award, highlights his exceptional contributions and the esteem in which he is held by the academic and research communities. His past honors from various prestigious institutions further validate his achievements.
5. Active Academic Engagement: Philippopoulos’s role in numerous conference presentations and his involvement as an editor and reviewer for academic journals show his active engagement in the scientific community. This participation underscores his dedication to both research and the dissemination of knowledge.

Areas for Improvement

1. Broader Research Collaborations: While Philippopoulos has been involved in several collaborative projects, expanding his network to include more international and interdisciplinary collaborations could enhance the scope and impact of his research.
2. Interdisciplinary Integration: There is an opportunity to further integrate his research with other scientific disciplines, such as materials science or environmental engineering, to address complex challenges from multiple perspectives.
3. Increased Public Outreach: Enhancing efforts to communicate his research findings to the general public and stakeholders outside the academic community could increase the societal impact and relevance of his work.
4. Funding and Grants: While Philippopoulos has been involved in research funded by various grants, seeking additional funding opportunities or leading larger-scale, multi-institutional projects could provide more resources for ambitious research goals.
5. Educational Contributions: Developing and incorporating innovative teaching methods or educational programs related to his research areas could further benefit students and early-career researchers, enriching the academic environment at his institution.

Conclusion

Athanassios Philippopoulos has made substantial contributions to inorganic chemistry, particularly in the areas of organometallic chemistry, renewable energy, and bio-inorganic chemistry. His extensive publication record, significant citations, and numerous awards reflect his outstanding research accomplishments and impact on the field. While there are areas for potential improvement, such as broadening collaborations and enhancing public outreach, his achievements and ongoing contributions position him as a leading figure in his field. The Best Researcher Award is a testament to his dedication and excellence in advancing scientific knowledge and addressing global challenges through chemistry.