Dr. Yuhao Liu | Molecular Biology | Best Paper Award

Dr. Yuhao Liu is a distinguished surgeon and researcher at The First Affiliated Hospital, Guangzhou University of Chinese Medicine. Holding both a Doctor of Medicine degree and a joint Ph.D. from the University of Western Australia, Dr. Liu has established a prominent career in orthopedics. He is known for his significant contributions to the field through extensive research, numerous publications, and innovations in orthopedic medicine. His role as Surgeon-in-charge underscores his leadership and expertise in both clinical and research settings.

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Dr. Liu has a notable academic footprint with 15 SCI papers and 6 Chinese papers as the first or corresponding author. He has been recognized with the ICOBR 2018 “Best Paper Award” for his outstanding contributions. His research impact is reflected in his high citation index, indicative of the relevance and influence of his work within the scientific community.

• Citations: 480 citations across 442 documents
• Number of Documents: 30
• h-index: 10

Education

Dr. Liu completed his Doctor of Medicine degree and pursued a joint Ph.D. from the University of Western Australia. His academic journey was further enriched by his role as a visiting scholar under a national government scholarship, which broadened his research perspective and international experience.

Research Focus

Dr. Liu’s research primarily centers on orthopedics, particularly exploring the pathological mechanisms of conditions such as femoral head necrosis. His work involves investigating oxidative stress and screening traditional Chinese medicine monomers for potential treatments in orthopedic diseases.

Professional Journey

Dr. Liu has had a dynamic career trajectory marked by leadership and research excellence. As a young scientific talent in Guangzhou, he has led numerous research projects funded by prestigious organizations such as the National Natural Science Foundation of China. His professional journey includes significant roles in academic and clinical settings, underpinned by his active participation in international orthopedic conferences.

Honors & Awards

Dr. Liu has received several prestigious awards, including the “Outstanding Doctoral Dissertation” and “Star of the Year” awards from his university. Additionally, his exceptional research work has been recognized internationally with the ICOBR 2018 “Best Paper Award,” highlighting his contributions to the field of orthopedics.

Publications Noted & Contributions

Dr. Liu has published extensively in high-impact journals, with 15 SCI papers and 6 Chinese papers to his name. His research has led to the discovery of the oxidative stress mechanism in femoral head necrosis and the screening of traditional Chinese medicine for orthopedic applications. His contributions are also evidenced by two authorized national invention patents.

“The Preserved Thickness Ratio of the Femoral Head Contributes to the Collapse Predictor of Osteonecrosis”

• Journal: Orthopaedic Surgery
• Publication Date: 2024
• DOI: 10.1111/OS.13967
• Contributors: Zhang, Jiahao; Zhou, Chi; Fan, Yinuo; Fang, Hanjun; Li, Weifeng; Wang, Xiyi; Chen, Zhenqiu; Liu, Yuhao
• Summary: This study explores how the preserved thickness ratio of the femoral head can predict collapse in osteonecrosis cases.

“Dihydrotanshinone I Attenuates Estrogen-Deficiency Bone Loss through RANKL-Stimulated NF-κB, ERK and NFATc1 Signaling Pathways”

• Journal: International Immunopharmacology
• Publication Date: October 2023
• DOI: 10.1016/j.intimp.2023.110572
• Contributors: Chao Ma; Liang Mo; Zhangzheng Wang; Deqiang Peng; Chi Zhou; Wei Niu; Yuhao Liu; Zhenqiu Chen
• Summary: This research investigates how Dihydrotanshinone I can mitigate bone loss associated with estrogen deficiency via specific signaling pathways.

“Dragon Blood Resin Ameliorates Steroid-Induced Osteonecrosis of Femoral Head Through Osteoclastic Pathways”

• Journal: Frontiers in Cell and Developmental Biology
• Publication Date: August 22, 2023
• DOI: 10.3389/fcell.2023.1202888
• Contributors: Yuhao Liu; Liang Mo; Hongduo Lu; Yangwenxiang Wei; Jiahao Zhang; Samuel Bennett; Jiake Xu; Chi Zhou; Bin Fang; Zhenqiu Chen
• Summary: This paper focuses on how Dragon Blood Resin can counteract steroid-induced osteonecrosis through effects on osteoclastic pathways.

“Loureirin B Downregulates Osteoclast Differentiation of Bone Marrow Macrophages by Targeting the MAPK Signaling Pathway”

• Journal: Scientific Reports
• Publication Date: August 23, 2022
• DOI: 10.1038/s41598-022-18287-5
• Contributors: Jiahao Zhang; Liang Mo; Haoran Huang; Jiake Xu; Yinuo Fan; Weifeng Li; Haibin Wang; Chi Zhou; Hanjun Fang; Wei He et al.
• Summary: The study evaluates how Loureirin B affects osteoclast differentiation through the MAPK signaling pathway.

“Integrated Analysis of Crucial Genes and miRNAs Associated with Osteoporotic Fracture of Type 2 Diabetes”

• Journal: BioMed Research International
• Publication Date: August 10, 2022
• DOI: 10.1155/2022/3921570
• Contributors: Liang Mo; Zhangzheng Wang; Haoran Huang; Jianxiong Li; Chao Ma; Jiahao Zhang; Fayi Huang; Wei He; Yuhao Liu; Chi Zhou et al.
• Summary: This article presents an integrated analysis of genes and miRNAs related to osteoporotic fractures in the context of Type 2 Diabetes.

Research Timeline

Dr. Liu’s research activities include the completion of 11 projects and involvement in consultancy and industry projects. His ongoing research continues to advance the understanding and treatment of orthopedic conditions, reflecting a consistent and impactful research trajectory.

Strengths of Dr. Yuhao Liu’s “Best Paper Award” Research

Innovative Contributions: Dr. Liu’s award-winning research, particularly in areas like oxidative stress mechanisms in femoral head necrosis and traditional Chinese medicine applications, showcases innovation and originality in the field of orthopedics. His focus on novel treatment pathways, such as those involving Dragon Blood Resin and Dihydrotanshinone I, demonstrates a forward-thinking approach to addressing complex orthopedic conditions.

High Citation Impact: The citation metrics of Dr. Liu’s work indicate substantial recognition and influence within the scientific community. With 480 citations across 442 documents, his research has clearly resonated with and impacted other scholars and practitioners in his field.

Interdisciplinary Approach: Dr. Liu’s research integrates traditional Chinese medicine with modern orthopedic practices, reflecting a multidisciplinary approach that can lead to more holistic and effective treatment strategies. This integration is valuable for broadening the scope and impact of his research.

Publication in High-Impact Journals: Dr. Liu’s work is published in reputable, high-impact journals such as Orthopaedic Surgery and International Immunopharmacology. These journals are known for their rigorous peer-review processes and wide readership, which further amplifies the visibility and influence of his research.

Recognition and Awards: The ICOBR 2018 “Best Paper Award” is a testament to the quality and relevance of Dr. Liu’s research. Such accolades not only enhance his professional reputation but also underscore the significance of his contributions to the field of orthopedics.

Areas for Improvement

Expanding Collaborative Networks: While Dr. Liu’s research is impactful, further expanding his collaborative networks, particularly with international researchers and institutions, could enhance the scope and applicability of his findings. Greater collaboration could lead to more diverse research perspectives and opportunities.

Increasing h-index: Dr. Liu’s h-index of 10, while respectable, indicates room for growth in terms of the number of highly cited papers. Continued focus on high-impact, widely cited research could enhance this metric, reflecting even greater influence within the academic community.

Diversifying Research Topics: While Dr. Liu’s focus on oxidative stress and traditional Chinese medicine is strong, exploring additional orthopedic topics or emerging trends in the field could further broaden his research impact and relevance.

Enhancing Public Engagement: Increasing efforts to communicate research findings to a broader audience, including through public talks, media appearances, or lay summaries, could help bridge the gap between academic research and public understanding. This could also enhance the practical impact of his work.

Improving Publication Frequency: While Dr. Liu has a substantial number of publications, increasing the frequency of high-quality publications could further strengthen his academic profile and contribute to ongoing advancements in orthopedic research.

Conclusion

Dr. Yuhao Liu’s research has made significant strides in the field of orthopedics, particularly through innovative approaches and the integration of traditional Chinese medicine. His recognition with the ICOBR 2018 “Best Paper Award” and high citation metrics reflect the impact and relevance of his work. To further enhance his research trajectory, Dr. Liu might consider expanding collaborative networks, diversifying research topics, and increasing public engagement. By addressing these areas, he can continue to build on his successes and drive further advancements in orthopedic medicine.