Dr. Batoul Rostom | Medicinal Chemistry Award | Best Researcher Award

Dr. Batoul Rostom | Medicinal Chemistry Award | Best Researcher Award

Dr. Batoul Rostom , INSERM-CRM , France

šŸŽ“ Dr. Batoul Rostom is a dedicated researcher in medicinal chemistry, currently a postdoctoral fellow at INSERM-Centre de Recherche en Myologie, Sorbonne University. She earned her Ph.D. in Medicinal Chemistry and Cancer Biology, where she focused on synthesizing novel cyclocoumarol derivatives with dual COX-2 inhibitory and anticancer properties. Dr. Rostom has a solid academic foundation in biochemistry and reproductive biology, with experience spanning bioinformatics, synthetic chemistry, and immunology. Her research addresses pressing issues in cancer therapeutics and autoimmune diseases. She has authored impactful publications, contributed to scientific conferences, and mentored students. Dr. Rostom’s work combines innovation with clinical relevance, aiming to bridge the gap between bench research and therapeutic applications.

Professional Profile:

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Summary of Suitability for Award:

Dr. Batoul Rostom’s remarkable achievements, interdisciplinary expertise, and impactful research make her a deserving candidate for the “Best Researcher Award.” Her ability to translate complex scientific concepts into therapeutic applications reflects her commitment to advancing both knowledge and societal well-being. Dr. Batoul Rostom exemplifies the qualities of an outstanding researcher, with her innovative contributions to medicinal chemistry and cancer biology. Her groundbreaking work in synthesizing cyclocoumarol derivatives as dual COX-2 inhibitors with anticancer properties showcases her ability to address pressing global health challenges. Ā Dr. Rostom’s impressive academic journey, from her Ph.D. at HESAM University to her postdoctoral role at Sorbonne University, highlights her dedication to advancing science.

šŸŽ“Education:

Dr. Batoul Rostom has a strong academic foundation in medicinal chemistry, biochemistry, and reproductive biology. She earned her Ph.D. in Medicinal Chemistry and Cancer Biology from HESAM University in France, where she focused on synthesizing novel cyclocoumarol derivatives with dual COX-2 inhibitory and anticancer properties. Her master’s degree in Reproductive Biology and Medical Aids from Lebanese UniversityĀ  centered on the impact of smoking on TET gene expression in sperm cells, optimizing RNA extraction techniques. She holds a bachelor’s degree in General Biochemistry from Lebanese University, with comprehensive training in molecular biology and biochemistry. Her education integrates interdisciplinary skills, blending synthetic chemistry, molecular biology, and bioinformatics.

šŸ¢Work Experience:

Dr. Batoul Rostom’s career spans diverse research roles. As a postdoctoral researcher at INSERM-Centre de Recherche en Myologie, Sorbonne University , she develops therapeutic strategies for autoimmune myositis and cancer. During her Ph.D. research at CNAM in France, she synthesized and tested innovative cyclocoumarol derivatives targeting COX-2 and cancer pathways.Ā  She led a COVID-19 PCR diagnostic team at Al Hadi Clinic, Lebanon, managing high-pressure operations during the pandemic. She has served as a private tutor , mentoring students in molecular biology and biochemistry. Her master’s internship explored smoking’s effects on male fertility, showcasing her diverse expertise.

šŸ…Awards:

Dr. Rostom’s remarkable achievements have earned her significant recognition in the field of medicinal chemistry. She was nominated for the prestigious International Chemistry Scientist Award for her groundbreaking contributions. As an active member of the SociĆ©tĆ© de Chimie ThĆ©rapeutique (SCT), her work in therapeutic compound design has been highly acknowledged. Her Ph.D. journey was supported by a competitive Scholarship Award, highlighting her academic excellence. Dr. Rostom also received the Top Oral Communication Award for her impactful presentations and the Young Research Fellow Distinction for her exceptional poster contributions at SCT’s events. These accolades underscore her innovation, dedication, and influence in advancing scientific research.

šŸ”¬Research Focus:

Dr. Rostom’s research spans medicinal chemistry, synthetic biology, and molecular biology. She specializes in designing novel cyclocoumarol derivatives, focusing on dual COX-2 inhibitors with anticancer properties. Her expertise extends to synthetic chemistry, developing compounds with pharmacological relevance. Molecular biology techniques, including RT-qPCR, ELISA, confocal microscopy, and cell culture, are central to her work. Her master’s research delved into reproductive biology, investigating smoking’s effects on male fertility. Presently, she focuses on autoimmune diseases, designing therapies for myositis while leveraging bioinformatics for in silico compound development. Her interdisciplinary approach aims to bridge laboratory research with clinical applications.

Publication Top Notes:

    • “Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments”
    • “Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways”
      • Citations: 34 citations

 

 

 

 

 

 

Dr. Sphelele Sosibo|Medicinal Chemistry|Best Researcher Award

Dr. Sphelele Sosibo|Medicinal Chemistry|Best Researcher Award

Dr. Sphelele Sosibo, North-West University, South Africa

Dr. Sphelele Cyril Sosibo is a Senior Lecturer in Organic Chemistry at North-West University in Mahikeng, South Africa. With extensive research and teaching expertise in pharmaceutical chemistry, Dr. Sosibo specializes in drug discovery for combating bacterial resistance and Alzheimer’s disease. He holds a Ph.D. in Chemistry from the University of Johannesburg, where he focused on molecular modeling of hydrolase inhibition. His research skills encompass synthesis, NMR, LCMS, and computational modeling, making significant contributions to publications on antimicrobial and anticancer compounds. Dr. Sosibo has supervised multiple graduate students, led various research projects, and actively contributes to academic and community outreach.

Professional Profile:

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Summary of Suitability for Award:

Dr. Sphelele C. Sosibo is an exceptional candidate for the “Best Researcher Awards,” as demonstrated by his extensive accomplishments in both research and education. His research on antibiotic resistance and bioactive phytochemicals showcases his innovative contributions to the field of pharmaceutical chemistry. Additionally, his strong record of teaching excellence, highlighted by the Certificate of Faculty Recognition in Teaching and Learning and multiple Certificates of Merit from the University of KwaZulu-Natal, reflects his dedication to education and student success. Together, these attributes underscore his impact as a researcher and educator, making him a deserving nominee for this prestigious award.

šŸŽ“Education:

Dr. Sphelele C. Sosibo’s educational background is a testament to his dedication and expertise in the field of chemistry. He earned his Doctor of Philosophy in Chemistry from the University of Johannesburg, where he focused on molecular modeling for drug discovery related to Alzheimer’s disease and antibiotic resistance. His Master of Medical Science in Pharmaceutical Chemistry from the University of KwaZulu-Natal involved the synthesis and characterization of novel ligands, showcasing his proficiency in organic synthesis and catalysis. Furthermore, his undergraduate studies, including a Bachelor’s degree in Applied Chemistry and an Honours degree in Chemistry, provided a solid foundation in the principles of chemistry, culminating in a mini-thesis on potential antimycobacterial candidates. This robust academic journey has equipped Dr. Sosibo with the knowledge and skills necessary to contribute significantly to pharmaceutical research.

šŸ¢Work Experience:

Dr. Sphelele C. Sosibo has a robust academic and research background, currently serving as a Senior Lecturer in Organic Chemistry at North-West University in Mahikeng, South Africa, since November 2022. He teaches both undergraduate and graduate courses while also conducting and supervising research focused on drug discovery. Prior to this, he held the position of Lecturer in Organic Chemistry at the same institution from January 2019 to November 2022, where he guided master’s and PhD researchers. His earlier experience includes a Lectureship at Durban University of Technology, where he taught analytical organic chemistry and supervised BTech research projects. Additionally, Dr. Sosibo gained international research experience as a Research Fellow at Uppsala University in Sweden and worked as a Research Assistant at the University of KwaZulu-Natal, contributing to organic chemistry research and laboratory management. His commitment to academic support was further demonstrated as a SI Leader at the University of KwaZulu-Natal, where he provided assistance to students in General Chemistry.

šŸ…Awards:

Dr. Sphelele C. Sosibo has received several notable awards that underscore his excellence in teaching and academic performance. He was honored with the Certificate of Faculty Recognition in Teaching and Learning from North-West University in 2021, highlighting his commitment to high-quality education. Additionally, during his time at the University of KwaZulu-Natal, he earned Certificates of Merit in Environmental Analysis III, Materials Chemistry III, and Physical Chemistry II between 2008 and 2009. Furthermore, Dr. Sosibo received Dean’s Commendations for his outstanding academic achievements in his BSc in Applied Chemistry and Cellular Biology, reflecting his dedication and excellence in the field of chemistry during his undergraduate studies.

šŸ”¬Research Focus:

Dr. Sosibo’s research primarily revolves around drug discovery, specifically targeting infections caused by resistant bacteria and Alzheimer’s disease. His work involves theoretical and bench-scale applications of organic, biochemical, and microbiological techniques. He employs various methodologies such as molecular docking, molecular dynamics simulations, and DFT calculations to investigate the interactions of bioactive phytochemicals and novel ligands with biological targets. Dr. Sosibo aims to develop innovative treatments for both communicable and non-communicable diseases, contributing to advancements in pharmaceutical chemistry.

Publication Top Notes:

  • Dual targeting approach for Mycobacterium tuberculosis drug discovery: insights from DFT calculations and molecular dynamics simulations
    • Citations: 20
  • Novel linear diamine disubstituted polycyclic ā€˜cage’ derivatives as potential antimycobacterial candidates
    • Citations: 18
  • Understanding the Hsp90 N-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and
    • Citations: 16
  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N, N′-dioxide ligands
    • Citations: 15
  • Impact of Pyridyl Moieties on the Inhibitory Properties of Prominent Acyclic Metal Chelators Against Metallo-β-Lactamase-Producing Enterobacteriaceae: Investigating the